For the past several years we have used "special" suitcases for cruising. They have two separate compartments. One for hanging garments and the other larger area for general packing.
We pack the hanging garments in cleaners plastic, and this really keeps the wrinkles down to almost nothing.
I use packing cubes for underwear, socks and polo style shirts. Actually two for the shirts. Make my unpacking very easy.
Each of us have this type of suitcase. They are 29" roller bags which are easy to handle in airports, etc.
In additon, Roe uses a matching Carry-on bag and I use a small day pack for medications, electronics and other important things which we do not check either on the plance or when boarding the ship.
Our luggage is bright RED which we enclose in heavy plastics covers, so there is no problem spotting ours at baggage claim. The covers keep the bags clean and very protected.
Other than that we don't do anything really special, but look forward to others ideas.